I was forwarded an article that seems boring, but had an interesting catch to it.
You may not have known this, but denitrosylation of HDAC2 by targeting Nrf2 restores glucocorticosteroid sensitivity in macrophages from COPD patients.
The study showed that in some forms of chronic inflammatory diseases, such as COPD/emphysema, acute respiratory distress syndrome, asthma, rheumatoid arthritis, and inflammatory bowel disease, a chemical reaction within a transcription factor called NRF2 within the cells causes them to be less sensitive to steroid therapy. When study patients with COPD were given either glutathione or sulforaphane, the chemical reaction was reversed and macrophages within the alveoli of the lungs became significantly more responsive to steroids.
One food that is high in both glutathione and sulforaphane is … broccoli.
Did a little extra research on the internet and found that glutathione is also contained in asparagus, potatoes and many green leafy vegetables and that sulforaphane is also contained in cabbage, cauliflower, bok choi, and those same green leafy vegetables.
And … one of the things that depletes glutathione in the body is Tylenol.
Also ran across a study in 2009 showing that the Nrf2 factor also plays a role in Helicobacter pylori infections and that ingestion of broccoli sprouts decreased byproducts of H. pylori infection by 40%.
Makes me wonder whether these chronic inflammatory diseases may have some type of bacteriologic basis.
Now they just have to do a study to find out many people would rather have COPD exacerbations than eat broccoli or green leafy vegetables every day.